Chronic Constipation Medication. Lubiprostone is a chloride-channel activator that acts locally in the gut to increase intestinal fluid secretion and intestinal motility, resulting in a laxative effect. For Adult 24â¯micrograms twice daily for 2–4 weeks, discontinue if no response after initial 2 weeks.
Capsules: 8 mcg and 24 mcg (3).
More on: Medications (Constipation)